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Neuromuscular Disorders presents a multi-disciplinary approach to the management and therapeutic treatment of the full range of neuromuscular disorders and resulting complications. Dr. Tulio Bertorini and a contributing team of the world’s leading authorities in the field provide the latest tools and strategies for minimizing disability and maximizing quality of life…in print and online at expertconsult.com.
Neuroscience: Exploring the Brain is a leading undergraduate textbook on the biology of the brain and the systems that underlie behaviour. This edition provides increased coverage of taste and smell, circadian rhythms, brain development, and developmental disorders and includes new information on molecular mechanisms and functional brain imaging.
Acclaimed for its clear, friendly style, excellent illustrations, leading author team, and compelling theme of exploration, Neuroscience: Exploring the Brain, 4e takes a fresh, contemporary approach to the study of neuroscience, emphasizing the biological basis of behaviour. The authors’ passion for the dynamic field of neuroscience is evident on every page, engaging students and helping them master the material. In just a few years, the field of neuroscience has been transformed by exciting new technologies and an explosion of knowledge about the brain.
This new edition of the well-regarded original has been thoroughly revised by Drs. John M. Mathis, Hervé Deramond, and Stephen M. Belkoff to reflect recent advances in percutaneous vertebroplasty and kyphoplasty. Obsolete sections have been judiciously replaced with cutting-edge material, such as an in-depth look at the latest bone cements and devices. Chapters outline spine anatomy, medical management, and patient selection. The addition of practical and challenging case studies furthers the focus of the previous edition by bridging the gap between theory and practice for spine interventionalists, radiologists, neuroradiologists, orthopedic surgeons, and neurosurgeons. The text is enhanced by a wealth of illustrations.
Featured in the Second Edition:
* New data on alternate routes for therapy, sacroplasty, and treating tumors
* New treatment techniques
* Updated examination of biomechanics
* New material on complications
* New figures and color images
* Inclusion of vertebroplasty and kyphoplasty cases
* Expanded presentation of ACR and SIR care standards
Sleep disorders cause considerable morbidity and distress in the aging population. By highlighting the clinical diagnosis and management of sleep disorders, this volume provides a valuable resource for all those involved in health care of older individuals. The changes in sleep patterns that occur during normal aging are described, followed by authoritative chapters on the presentation of various age-related sleep disorders. The book deals with the range of therapeutic measures available for managing these disorders and gives insight to potential areas of research that have emerged in the last few years, such as the study of circadian rhythms in later life, sleep patterns associated with co-morbidities and the use of quality-of-life measurement tools to determine sleep quality as we age. This volume is relevant to sleep disorders specialists, psychiatrists, geriatricians and gerontologists, and any professionals and researchers working in the interdisciplinary areas of sleep and aging.
Published annually, volumes in this series provide readers with updates of clinical trial results, impacts of trials on guidelines and evidence-based practice, advances in trial methodologies, and the evolution of biomarkers in trials. The series focuses on trials in neurotherapeutics, including disease-modifying and symptomatic agents for neurological diseases, psychopharmacological management of neurologic and psychiatric illnesses, and non-drug treatments. Each paper is authored by a leader in the area of neurotherapeutics and clinical trials, and the series is guided by an editor-in-chief and editorial board with broad experience in drug development and neuropsychopharmacology. Progress in Neurotherapeutics and Neuropsychopharmacology is an essential update of trials in all aspects of the management of neurologic and neuropsychiatric disorders, and will be an invaluable resource for practising neurologists as well as clinical and translational neuroscientists.
It is becoming increasingly realized that adenosine plays an important role in the central metabolism and blood flow and that therapeutic possibilities may arise from the pharmacological manipulation of the adenosine system. The growing interest in this field has prompted a group of international experts to contribute to this volume on adenosine. The book contains thorough reviews on adenosine research and presents numerous new ideas and data on the role and function of adenosine in the mammalian brain.
Sleep Deprivation, Stimulant Medications, and Cognition provides a distillation of the literature surrounding stimulant medications and cognitive performance, with an emphasis on critical evaluation of the potential practical utility of these agents for restoring and maintaining cognitive performance in sleep-deprived individuals – key reading for researchers interested in sleep loss and psychopharmacology.
The relationship between sleep disorders – in particular sleep apnea, a highly prevalent condition – and common vascular disturbances such as stroke and hypertension is an area of active research. Summarizing the clinical evidence to date between sleep disorders and vascular pathology, this is the first time a comprehensive overview of this relationship has been covered in a single volume. Bringing together some of the world’s most renowned authors in the field, Sleep, Stroke and Cardiovascular Disease contains recommended treatment plans – allowing for rapid and accurate diagnosis and management of patients – enabling learning from real experience. Of interest, not only, to specialists who intervene in diagnosis and management of sleep and stroke disorders such as neurologists, cardiologists and pulmonologists, the book will also be of value to primary-care practitioners, allowing them to arrive at better diagnoses and management of sleep and vascular disorders.
Written and edited by leading clinicians and researchers in sleep medicine, this is the first book to focus on the causes, consequences and treatment of disorders of excessive sleepiness. Extensive coverage is provided for all known causes of sleepiness, including sleep deprivation, obstructive sleep apnea syndrome, narcolepsy and other hypersomnias of central origin, shift work, and medical and psychiatric disorders. Since many causes of sleepiness are difficult to differentiate from each other, and treatment modalities can vary greatly from one disorder to another, this book helps the clinician to formulate a differential diagnosis that will ultimately lead to the correct diagnosis. Epidemiology, evaluation of the sleepy patient, diagnostic investigations including neuroimaging, subjective and objective testing, cognitive effects of sleepiness, motor vehicle driving issues, medico-legal aspects of sleepiness, and therapy are also discussed in detail. This is an essential resource for neurologists, psychiatrists and sleep specialists.
“There are an estimated 4,800,000 stroke survivors living today and about 700,000 people suffer a new or recurrent stroke each year. Stroke is one of the most common disabling medical conditions, and has wide-ranging economic, social, and psychological effects.
Stroke, the fourth volume in a series sponsored by the American Academy of Neurology, was written for both stroke survivors and individuals wishing to learn more about the condition and how to prevent it. Friends and families of stroke patients will find it a valuable resource packed with important coping tips and management techniques. Nurses, social workers, public health officials, and other caregivers will also benefit from this informative text, which covers:
Written by one of the most respected doctors in the field, Stroke is easily accessible, avoids medical jargon, and focuses not just on the patient but on the community and those close to the survivor. This essential guide will help to ensure that patients are provided with both the medical and personal care they need and will make this most difficult of circumstances a bit easier for all involved.”
Studies of human movement have proliferated in recent years. This greatly expanded and thoroughly updated reference surveys the literature on the corticospinal control of spinal cord circuits in human subjects, showing how different circuits can be studied, their role in normal movement and how they malfunction in disease states. Chapters are highly illustrated and consistently organised, reviewing, for each pathway, the experimental background, methodology, organisation and control, role during motor tasks and changes in patients with CNS lesions. Each chapter concludes with a helpful résumé that can be used independently of the main text to provide practical guidance for clinical studies. The final four chapters bring together the changes in transmission in spinal and corticospinal pathways during movement and how they contribute to the desired movement. This book is essential reading for research workers and clinicians involved in the study, treatment and rehabilitation of movement disorders.
Criminological theory dating back one hundred years has been aware of the need to develop a neurobiology of extroversion, impulsivity, frontal-lobe dysfunction, and aggressive behavior, yet in the twentieth century criminologists have largely forsaken this psychobiological legacy. The Neurobiology of Criminal Behavior looks at this legacy with reference to a variety of neurobiological methodologies currently in vogue. The authors are all distinguished researchers who have contributed considerably to their respective fields of psychiatry, psychology, psychobiology, and neuroscience.
To understand how the brain learns and remembers requires an integration of psychological concepts and behavioral methods with mechanisms of synaptic plasticity systems and systems neuroscience. The Neurobiology of Learning and Memory is a new undergraduate textbook that provides a synthesis of this interdisciplinary field. Each chapter makes the key concepts transparent and accessible to a reader with a minimal background in either neurobiology or psychology and is extensively illustrated with full-color photographs and line art depicting important concepts and experimental data. The first section of the book is organized around the central ideas that synapses are plastic and can be modified by experience and that the synapse is the basic unit of information storage. It introduces students to the long-term potentiation methodology used to study how synapses are modified, the concepts of post-translation processes, genomic signaling processes, local protein synthesis and synaptic tagging, and how they contribute to strengthening synapses. It emphasizes the various ways calcium regulates processes that strengthen synapses and ends with a discussion on the structure of dendritic spines and how changes in the spine s structure contribute to its function and stability. The second section builds on this foundation to show how molecules and cellular processes that have been identified from studies of synaptic plasticity also participate in the making of memories. It features a discussion of the basic conceptual issues researchers face in trying to relate memory to molecules and describes some of the behavioral and neurobiological methods that are used. This section also introduces the concept of memory modulation and discusses the fate of retrieved memories and how they can be modified. The final section of the book is organized around the multiple memory systems view that different neural systems have evolved to store the content contained in our experience. It features discussion of the medial-temporal hippocampal system that supports episodic memory, the concept of systems consolidation, and its relationship to Ribot s law that memories become resistant to disruption as they age. The cortico-striatal system and its relationship to what are called behavioral actions and habits is described, and this section ends with a discussion of neural systems involved in the acquisition and removal of emotional memories.
Brings together two often isolated lines of research to present a wide ranging exploration of speech and language processing – from phonetics and psycholinguistics to neuroimaging and neuroanatomy. Written and edited by top researchers in the brain sciences, and presenting work from leading research centres throughout the world.Shows how an approach that spans disciplines can help provide answers to the myriad of questions that remain unanswered in the field of speech communication
ranslational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. The focus of this book is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Translational Neuroimaging: Tools for CNS Drug Discovery,
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