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Genetic Instabilities and Neurological Diseases covers DNA repeat instability and neurological disorders, covering molecular mechanisms of repeat expansion, pathogenic mechanisms, clinical phenotype, parental gender effects, genotype-phenotype correlation, and diagnostic applications of the molecular data. This updated edition provides updates of these repeat expansion mutations, including the addition of many new chapters, and old chapters rewritten as extensions of the previous edition. This book is an invaluable reference source for neuroscientists, geneticists, neurologists, molecular biologists, genetic counsellors and students.
Our understanding of the relationship between genetics and pulmonary disorders is still developing. In 1989 cloning of the gene that, when mutated, causes Cystic Fibrosis marked a great advance in the study of genetic diseases. Yet, over a decade later, understanding of how this genetic defect leads to colonization by bacteria and inflammation in the lung remains elusive. This is proving to be an engaging area of investigation for many medical professionals, with research into the effects of these genetic variations on various diseases in progress. Genetics for Pulmonologists provides an overview of lung diseases for which the genetic defect has been defined as of June 2001. It is an easy-to-use manual with concise reviews of genetic diseases that a pulmonologist might encounter.
n a candid memoir, Burney paints a vivid picture of leading politicians, including Pierre Trudeau using an off-colour joke to break the ice with Ronald Reagan, Colin Powell becoming upset over Canadian concerns about collateral damage in the first Gulf War, and George Bush Sr chafing at the excessive European flavour of G-7 summits.
This second Glaucoma volume of the Essentials in Ophthalmology series, like the first, provides a comprehensive picture of recent progress in both basic clinical research and applied clinical science in the study of glaucoma. Rather than a replacement for traditional textbooks on glaucoma, this volume serves as a conceptual bridge between original research and textbook presentation. The book encompasses frequently unmentioned aspects of therapy, including adherence, persistence and health economics. Glaucoma II provides the reader with diverse and salient topics reflective of the contemporary, evidence-based approach to the study, treatment and management of glaucoma.
When reason fails to guide us in our everyday lives, we turn to faith, to religion; we close our minds; we reject austere reasoning. This rejection, which is a faith-based social and intellectual malignancy, has two unfortunate consequences: it blocks the way to knowledge that might enhance the quality of life and it opens the way to charlatans who exploit the faith of others. Examining two unquestionable malignancies of “the Christian Right” in present-day politics in the United States and the “secular religion” of Hitler’s National Socialism, as well as the third, more complex case of Gandhi, the author asserts that we need religion, but we also need to make sure it does no harm.
The Durkheimians have traditionally been understood as positivist, secular thinkers, fully within the Enlightenment project of limitless reason and progress. In a radical revision of this view, this book persuasively argues that the core members of the Durkheimian circle (Durkheim himself, Marcel Mauss, Henri Hubert and Robert Hertz) are significantly more complicated than this. Through his extensive analysis of large volumes of correspondence as well as historical and macro-sociological mappings of the intellectual and social worlds in which the Durkheimian project emerged, the author shows the Durkheimian project to have constituted a quasi-religious quest in ways much deeper than most interpreters have thought. Their fascination, both personal and intellectual, with the sacred is the basis on which the author reconstructs some important components of modern French intellectual history, connecting Durkheimian thought to key representatives of French poststructuralism and postmodernism: Bataille, Foucault, Derrida, Baudrillard, and Deleuze.
Going Global for the Greater Good offers a unique look at the way nonprofits—of any size—can increase their impact and better achieve their missions by engaging in the international community. Nonprofits that see themselves as part of a global community can provide a broader reach for programs, enhance the diversity of their organizations, raise their organizations’ profiles, and benefit from the ideas and experience of the global nonprofit community. But few organizations know how to take their place at the international table, and many smaller organizations don’t know whether it is realistic for them to try. This practical, user-friendly guide helps locally based organizations find connections in the ever-expanding global arena of ideas.
‘A mixture of science fiction and folktale, past and future, primitive and present-day . . . Thunderous and touching.’
Financial Times
After drinking an elixir that bestows immortality upon him, a young Indian named Flapping Eagle spends the next seven hundred years sailing the seas with the blessing — and ultimately the burden — of living forever. Eventually, weary of the sameness of life, he journeys to the mountainous Calf Island to regain his mortality. There he meets other immortals obsessed with their own stasis and sets out to scale the island’s peak, from which the mysterious and corrosive Grimus Effect emits. Through a series of thrilling quests and encounters, Flapping Eagle comes face-to-face with the island’s creator and unwinds the mysteries of his own humanity. Salman Rushdie’s celebrated debut novel remains as powerful and as haunting as when it was first published more than thirty years ago.
‘A book to be read twice . . . [Grimus] is literate, it is fun, it is meaningful, and perhaps most important, it pushes the boundaries of the form outward.’
Providing a thorough and up-to-date overview of the full range of gynaecological cancers, Gynaecological Oncology is a concise introduction, particularly useful for trainees working towards postgraduate examinations. The first section includes introductory chapters on epidemiology, screening and prevention, imaging, pathology, surgery, radiation therapy, chemotherapy, and palliation. The second part of the book covers the gynaecological cancer types in turn; each chapter following a similar format looking at clinical issues, staging, and principles of management. Where appropriate, flow-charts and diagrams are used to help the reader assimilate complex information. A chapter is devoted to decision-making, addressing those issues clinicians and women face when deciding on optimal management in given clinical scenarios. The book is practically based and is enhanced by highlighting learning points, management algorithms and clinical images. This is an invaluable resource for all doctors and allied health professionals dealing with women with gynaecological cancers.
Hair Transplantation in Cosmetic Dermatology is a fully illustrated reference book that provides a state-of-the-art overview to all aspects of hair transplantation. Using a combination of written text, color photographs, and tables, eleven leading physicians and practitioners in the field discuss the latest surgical procedures to restore a natural-looking frame of hair to the face. This volume is an indispensable reference for dermatologists, practitioners, and residents, providing an extensive coverage of the latest procedures and instruments in hair restoration surgery, techniques for follicular unit extraction, Cicatricial alopecia, and eyelash transplantation.
Breast MRI is no longer the domain of specialised centres; it is now a mainstream diagnostic technique, and an understanding of its applications is essential for any clinician involved with breast imaging. The Handbook of Breast MRI provides core knowledge and clinical guidelines for performing breast MRI in everyday practice. Introductory chapters on breast MRI basics, anatomy and pathology are followed by detailed chapters on the use of MRI in screening, staging, problem-solving and MRI-guided interventions, each containing diagnostic algorithms, tables and lists for quick access to key diagnostic information. Each chapter also contains a selection of self testing questions, and numerous Appendices concisely summarise tumour classification and current breast cancer treatment options. The Handbook of Breast MRI is an invaluable practical diagnostic resource for radiologists, surgeons, oncologists and all clinicians involved in breast cancer management.
An essential guide on formulation for administration to a patient with limited GI access and will be essential reading for all pharmacists, doctors, nurses, dieticians in hospitals, community pharmacists and GPs. The second edition of this practical guide to the safe administration of medicines via enteral feeding tubes has been revised and updated to include 40 new monographs adding to the comprehensive collection. Ten chapters provide the background knowledge to inform clinical decisions, including information on: * types of enteral feeding tubes, syringes and ports * flushing, restoring and maintaining patency * drug therapy review * choice of medication formulation * legal and professional consequences of administering drugs via enteral feeding tubes * health and safety and clinical risk management * defining interactions
Geared to a wide readership of practicing clinicians and trainees in primary care medicine and gastroenterology, this handbook offers practical information on Crohn’s disease and ulcerative colitis. Coverage begins with the patient’s first visit and proceeds through the diagnostic workup: endoscopy, radiologic testing, and instruments for rating and classifying inflammatory bowel disease. Discussions of therapy include conventional therapies, immunomodulators, biologic therapies, surgical approaches, and intestinal stomas. Chapters discuss extraintestinal manifestations of inflammatory bowel disease, inflammatory bowel disease and the liver, infections, and pouchitis. Additional chapters focus on nursing considerations, nutrition, women’s health issues, and inflammatory bowel disease and the workplace.
A practical, clinically-oriented handbook of iron overload disorders giving a compact guide to normal iron metabolism, iron-related pathobiology, and the diagnosis and management of heritable and acquired iron overload disorders. Many of these disorders were discovered and characterized only in the last decade, and are unmentioned or inadequately described in most texts. Written by clinicians for clinicians, this handbook summarizes information on diverse iron overload conditions, including their history, signs, symptoms, and physical examination findings, genetics, genotype-phenotype correlations, pathophysiology, differential diagnosis and treatment. Most physicians, regardless of specialty, encounter patients with systemic or organ-specific iron overload conditions. This book contains essential information for practising adult and pediatric medical specialists in the fields of hematology, gastroenterology, hepatology, rheumatology, endocrinology, diabetology, neurology, oncology, dermatology, and internal medicine. Pathologists, pharmacologists, geneticists, genetic counselors, and epidemiologists will also find substantial, up-to-date sections in this handbook that are pertinent to their respective fields of interest.
The fifth volume in this series covers emotional behavior and its disorders. The introductory chapters deal with the basic theoretical and anatomical issues in the neuropsychological study of emotions. Both neurobiologically oriented and cognitively oriented theories of emotion are presented and both the detailed anatomo-clinical and theoretical aspects of the anatomical substrates of emotions are covered in depth. The central part of this volume addresses the problem of hemispheric asymmetries in emotional representation. The claims for right hemisphere dominance for emotions and emotional communication are contrasted with those assuming a different hemispheric specialization for positive vs. negative emotions and with models assuming asymmetric cortico-limbic control of human emotion. A final group of chapters examines the neural mechanisms of the stress response and reviews the main emotional disorders. Individual differences in the hemispheric control of the stress response are discussed and the neural mechanisms of affective/emotional disturbances are approached with neuropsychological methods and with functional neuroimaging techniques.
The Handbook of Polygraph Testing examines the fundamental principles behind lie detector tests and provides an up-to-date review of their validity. The editor presents current psychological theories, including an explanation of the cognitive processes central to polygraph testing. He describes the various methods of testing, the research in support of each method, and special issues in polygraph research. The Handbook helps readers interpret existing research studies, and learn how to improve the accuracy of polygraph testing and analysis.
This book offers an overview of topics related to neurobiological impairments which are related to the ageing brain and nervous system. Coverage ranges from animal models to human imaging, fundamentals of age-related neural changes and pathological neurodegeneration, and offers an overview of structural and functional changes at the molecular, systems, and cognitive levels. Key pathologies such as memory disorders, Alzheimer’s, dementia, Down syndrome, Parkinson’s, and stroke are discussed, as are cutting edge interventions such as cell replacement therapy and deep brain stimulation. There is no other current single-volume reference with such a comprehensive coverage and depth.
A single volume of 85 articles, the Handbook of the Neurobiology of Aging is an authoritative selection of relevant chapters from the Encyclopedia of Neuroscience, the most comprehensive source of neuroscience information assembled to date (AP Oct 2008).
The study of neural aging is a central topic in neuroscience, neuropsychology and gerontology. Some well-known age-related neurological diseases include Parkinson’s and Alzheimer’s, but even more common are problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging become more common and conditions associated with aging need more attention by doctors and researchers.
This book offers an overview of topics related to neurobiological impairments which are related to the aging brain and nervous system. Coverage ranges from animal models to human imaging, fundamentals of age-related neural changes and pathological neurodegeneration, and offers an overview of structural and functional changes at the molecular, systems, and cognitive levels. Key pathologies such as memory disorders, Alzheimer’s, dementia, Down syndrome, Parkinson’s, and stroke are discussed, as are cutting edge interventions such as cell replacement therapy and deep brain stimulation. There is no other current single-volume reference with such a comprehensive coverage and depth.
This abbreviated version of Hands Heal, Third Edition is a practical guide to documentation in wellness massage. It is designed for massage therapists who do not provide therapy that would require physician referrals or insurance billing.
Hands Heal Essentials offers wellness charting guidelines for energy work, on-site massage, and relaxation and spa therapies, along with sample completed forms and blank forms. Crucial information on HIPAA regulations is included.
A front-of-book CD-ROM includes the blank forms for use in practice, a quick-reference abbreviation list, and a quiz tool to review key concepts. Faculty ancillaries are available upon adoption.
The premier reference on pediatric ophthalmology is now in its thoroughly updated Fifth Edition. More than 40 eminent authorities cover every aspect of pediatric eye care—from genetics through reading disorders—focusing on clinical diagnosis and management. More than 700 illustrations complement the text.
New Fifth Edition chapters cover Neonatal Ophthalmology, Surgical Management of Strabismus, Medicolegal Issues, and Evolution of Strabismus Surgery. All other chapters have been updated to include recent advances in genetics, newly recognized syndromes, and state-of-the-art management protocols.
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