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Intercellular communication is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their environment is the basis for growth and development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancer, autoimmunity, diabetes, and neurological and psychiatric disorders. There is substantial drug development concentrating on this and intercellular communication is the basis of much of neuropharmacology. By understanding cell signalling, diseases may be treated effectively and, theoretically, artificial tissues may be yielded. Neurotransmitters/receptors, synaptic structure and organization, gap junctions, neurotrophic factors and neuropeptides are all explored in this volume, as are the ways in which signalling controls neuroendocrinology, neuroimmunology and neuropharmacology. Intercellular Communication in the Nervous System provides a valuable desk reference for all scientists who consider signalling.
Pharmacotherapy Principles & Practice, Third Edition uses a solid evidence-based approach to teach you how to design, implement, monitor, and evaluate medication therapy. This trusted text provides everything you need to gain an in-depth understanding of the principles essential to the optimal pharmacotherapy of disease. In order to be as clinically relevant as possible, the disease states and treatments discussed focus on disorders most often seen in clinical practice. Chapters were written or reviewed by pharmacists, nurse practitioners, physician assistants, and physicians who are authorities in their fields.
The book opens with an introductory chapter followed by chapters on paediatrics, geriatrics, and palliative care. The remainder of the text consists of ninety-eight disease-based chapters that review etiology, epidemiology, pathophysiology, and clinical presentation, followed by therapeutic recommendations for drug selection, dosing, and patient monitoring.
This book offers an overview of topics related to neurobiological impairments which are related to the ageing brain and nervous system. Coverage ranges from animal models to human imaging, fundamentals of age-related neural changes and pathological neurodegeneration, and offers an overview of structural and functional changes at the molecular, systems, and cognitive levels. Key pathologies such as memory disorders, Alzheimer’s, dementia, Down syndrome, Parkinson’s, and stroke are discussed, as are cutting edge interventions such as cell replacement therapy and deep brain stimulation. There is no other current single-volume reference with such a comprehensive coverage and depth.
Eleven-year-old Malcolm Polstead and his dæmon, Asta, live with his parents at the Trout Inn near Oxford. Across the River Thames (which Malcolm navigates often using his beloved canoe, a boat by the name of La Belle Sauvage) is the Godstow Priory where the nuns live. Malcolm learns they have a guest with them, a baby by the name of Lyra Belacqua . . .
Jack Reacher takes an aimless stroll past a pawn shop in a small Midwestern town. In the window, he sees a West Point class ring from 2005. It’s tiny. It’s a woman cadet’s graduation present to herself. Why would she give it up? Reacher’s a West Pointer too, and he knows what she went through to get it.
Reacher tracks the ring back to its owner, step by step, down a criminal trail leading west. Like Big Foot come out of the forest, he arrives in the deserted wilds of Wyoming. All he wants is to find the woman. If she’s OK, he’ll walk away. If she’s not … he’ll stop at nothing.
He’s still shaken by the recent horrors of Make Me, and now The Midnight Line sees him set on a raw and elemental quest for simple justice. Best advice: don’t get in his way.
End Game is the fifth book in the thrilling Will Robie series by the international number one bestselling author David Baldacci.
Will Robie, highly trained assassin and the US government’s most indispensable asset, is called to London.
An imminent terrorist attack threatens the Underground and with the US next in line, Robie is the perfect choice to stop it before it begins.
He knows he has one chance to succeed. One chance to save London. One chance to make it safely home to find out what has happened to fellow agent Jessica Reel following their last deadly mission together.
But Robie is about to learn that even if he succeeds, the worst is yet to come.
The game has started. Now only he can end it . . .
Amos Decker, David Baldacci’s unique special agent, who suffered a head injury that resulted in giving him the gift of a remarkable memory takes on another case in The Fix.
Walter Dabney is a family man. A loving husband and the father of four grown daughters, he’s built a life many would be proud of.
But then the unthinkable happens.
Standing outside the FBI Headquarters in Washington, DC, Dabney shoots school teacher Anne Berkshire in cold blood before turning the gun on himself.
What will happen to Stevens when he reaches Lord Darlington’s? Will he and Miss Kenton find a second chance at love? The Remains Of The Day: Booker Prize Winner 1989 was published in 2010 by Faber in paperback.
A novel of explosive suspense, heroic action – and evil on an epic scale. In the hands of Mario Puzo’s brilliantly sinister talent, the reader comes to know again the terrible magic of the Mafia.
New York – a mob boss is assassinated. His nephew Astorre Viola and the head of the city’s FBI both launch investigations into the murder. But this time silence spreads like a contagion: the silence of rival gangs, the silence of crooked bankers, even the silence of the courts. The world of the Mafia is riven with greed, and Viola knows that now is the time to claim his destiny…
Ishiguro’s extraordinary and original study of a man whose life has accelerated beyond his control was met on publication by consternation, vilification – and the highest praise.
A wonderful, beautifully told tale from America’s favourite novelist, Fairytale is a captivating example of the truths that will always withstand even the darkest storms and a reminder that sometimes fairytales do come true, and good prevails over evil in the end.
No Mud, No Lotus is an immensely practical guide to overcoming life’s big and little problems.
The last don is Domenico Clericuzio, a wise and ruthless man who is determined to see his heirs established in legitimate society but whose vision is threatened when secrets from the family’s past spark a vicious war between two blood cousins.
Eleven Minutes is the story of Maria, a young girl from a Brazilian village, whose first innocent brushes with love leave her heartbroken. At a tender age, she becomes convinced that she will never find true love, instead believing that “love is a terrible thing that will make you suffer. . . .” A chance meeting in Rio takes her to Geneva, where she dreams of finding fame and fortune.
Maria’s despairing view of love is put to the test when she meets a handsome young painter. In this odyssey of self-discovery, Maria has to choose between pursuing a path of darkness—sexual pleasure for its own sake—or risking everything to find her own “inner light” and the possibility of sacred sex, sex in the context of love.
A high-speed cops and robbers adventure with heart and soul with a father and son taking on the villainous Mr Big – and winning!
This riches-to-rags story will have you on the edge of your seat and howling with laughter!
Bad Dad is a fast and furious, heart-warming story of a father and son on an adventure – and a thrilling mission to break an innocent man into prison!
Award-winning author Sudha Murty walks by your side, weaving enchanting tales of the three most powerful gods from the ancient world. Each story will take you back to a magical time when people could teleport, animals could fly and reincarnation was simply a fact of life.
Neuromuscular Disorders presents a multi-disciplinary approach to the management and therapeutic treatment of the full range of neuromuscular disorders and resulting complications. Dr. Tulio Bertorini and a contributing team of the world’s leading authorities in the field provide the latest tools and strategies for minimizing disability and maximizing quality of life…in print and online at expertconsult.com.
FEATURES
CURRENT Diagnosis & Treatment Neurology, 2e provides busy clinicians with practical, up-to-date strategies for assessing and managing the most frequently seen neurologic conditions in adults and children.
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